The Mechanisms and Benefits of PERQUE Choline Citrate™

 

Choline is an essential nutrient that plays a critical role in various physiological processes, including neurotransmitter synthesis, cell membrane integrity, lipid metabolism, and methylation. Despite its importance, many individuals fail to obtain adequate choline from their diet, leading to a range of cognitive and physical health issues. PERQUE Choline Citrate™ offers a bioavailable form of choline, providing the necessary support for individuals with increased choline demands or impaired choline metabolism.

 

Ingredients and Mechanisms of Action

  1. Choline Citrate

    • Neurotransmitter Synthesis: Choline is a precursor for acetylcholine, a neurotransmitter crucial for memory, mood regulation, and muscle control. PERQUE Choline Citrate™ provides choline in a citrate form, ensuring rapid absorption and utilization in the body.
    • Magnesium Uptake: PERQUE Choline Citrate™ enhances the uptake of magnesium, an essential mineral involved in over 300 biochemical reactions in the body, including nerve transmission, muscle contraction, and energy production. The citrate component facilitates the neutral charge needed to transport magnesium across cell membranes efficiently.
    • Liver Detoxification: Choline is vital for liver health, as it is involved in the production of phosphatidylcholine, a component of very-low-density lipoprotein (VLDL) that helps transport fat out of the liver. By improving choline availability, PERQUE Choline Citrate™ supports lipid metabolism and reduces the risk of non-alcoholic fatty liver disease.

  2. Glycerin (Vegetable)

    • Absorption and Bioavailability: Glycerin acts as a solvent and stabilizer, ensuring the stability and bioavailability of choline in the liquid form. It also provides a smooth texture and taste, making the supplement easier to consume.

 

Physiological Impact

  • Cognitive Function: Adequate choline intake is essential for the production of acetylcholine, which supports memory, learning, and overall cognitive function. PERQUE Choline Citrate™ has been shown to improve memory and cognitive performance in individuals with choline deficiency or increased cognitive demands.
  • Physical Performance: Choline is necessary for the synthesis of phosphatidylcholine, a critical component of cell membranes, including those of muscle cells. This supports efficient muscle function, reduces the risk of exercise-induced muscle damage, and enhances overall physical performance.
  • Magnesium Synergy: By improving magnesium uptake, PERQUE Choline Citrate™ indirectly supports muscle relaxation, energy production, and the regulation of the stress response. This makes it particularly beneficial for individuals with chronic fatigue syndrome, fibromyalgia, or other conditions associated with magnesium deficiency.

 

Clinical Applications

PERQUE Choline Citrate™ is recommended for individuals with:

  • Cognitive Decline: Including age-related memory loss, Alzheimer’s disease, and other neurodegenerative conditions.
  • Chronic Fatigue and Fibromyalgia: Where impaired magnesium uptake contributes to fatigue, muscle pain, and cognitive issues.
  • Liver Health: To support lipid metabolism and reduce the risk of fatty liver disease.

 

PERQUE Choline Citrate™ is a unique and highly effective supplement that addresses the widespread issue of choline deficiency. By providing bioavailable choline and enhancing magnesium uptake, it supports cognitive function, physical performance, and liver health. Its liquid form ensures maximum absorption, making it an ideal choice for individuals with increased choline needs or impaired nutrient absorption.

 

References

  1. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP choline) for cognitive and behavioral disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst. Rev. 2005 Apr 18;(2)
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  2. Canty DJ, Zeisel SH. Lecithin and choline in human health and disease. Nutr Rev. 1994; 52: 327-339.
  3. Zeisel SH. Choline: needed for normal development of memory. J Nutr. 2000 May; 130(5 Suppl):528S-531S.
  4. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Ann Rev Nutr.2006;26:229-50.
  5. Spector SA, Jackman MR, Sabounjian LA, Sachs L, Landers DM, Williams VVT. Exercise and neuromodulators: choline and acetylcholine in marathon runners. Int J Sports Med. 1995 May; 27(5): 668-73.
  6. Conlay LA, Sabounjian LA, Wurtman RJ. Exercise and neuromodulators: choline and acetylcholine in marathon runners. Int J Sports Med. 1992 Oct; 13 Suppl 1
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  7. Secades JJ, Lorenzo JL. Citicoline: Pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol. 2006 Sep;28 Suppl B:1-56.
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