CytoQuel®: Comprehensive Analysis and Mechanisms of Action in Cytokine Support

 

CytoQuel® is a dietary supplement designed to modulate cytokine levels and support a balanced inflammatory response. This paper provides a detailed analysis of its ingredients, the physiological role of cytokines, and the evidence supporting its efficacy.

 

Understanding Cytokines

 

Cytokines are small proteins released by cells, particularly those of the immune system, which act as signaling molecules to regulate immunity, inflammation, and hematopoiesis. They include interleukins, interferons, tumor necrosis factors, and growth factors, among others.

 

Physiology of a Healthy Cytokine Response

 

During an infection or injury, the body naturally increases the production of pro-inflammatory cytokines such as IL-1, IL-6, TNF-α, and others. These cytokines help in recruiting immune cells to the site of infection or injury, promoting inflammation and healing. Once the threat is neutralized, anti-inflammatory cytokines such as IL-10 and TGF-β are produced to dampen the inflammatory response and promote tissue repair. An imbalance in this process can lead to chronic inflammation and associated diseases.

 

Ingredients of CytoQuel® and Their Mechanisms

 

  1. N-acetyl cysteine (NAC)

    • Function: NAC is a precursor to glutathione, a powerful antioxidant. It modulates levels of NF-kB, a protein complex that controls transcription of DNA, cytokine production, and cell survival. By reducing oxidative stress, NAC indirectly supports the balance of pro- and anti-inflammatory cytokines.
    • Benefits: Promotes healthy levels of NF-kB, IL-6, IL-8, reducing oxidative stress and inflammation.

  2. Black Tea Extract (containing EGCG)

    • Function: EGCG (epigallocatechin gallate) is a type of catechin with strong antioxidant properties. It modulates immune responses by inhibiting the production of pro-inflammatory cytokines and enhancing the activity of anti-inflammatory cytokines.
    • Benefits: Promotes healthy levels of IL-23 and IL-17, supports NF-kB, TNF-α, IL-1 beta, IL-6, IL-8, and mitigates inflammation.

  3. CurcuWIN™ Turmeric Extract

    • Function: Curcumin, the active component of turmeric, has well-documented anti-inflammatory and antioxidant effects. CurcuWIN™ utilizes UltraSOL™ technology to enhance bioavailability, ensuring more efficient absorption.
    • Benefits: Promotes healthy levels of IL-6, IL-17, IL-21. The enhanced bioavailability ensures better anti-inflammatory action.

  4. DeltaGold® Tocotrienols

    • Function: Tocotrienols are members of the vitamin E family with potent antioxidant properties. They modulate the activity of NF-kB and nitric oxide, which are key players in inflammation.
    • Benefits: Promotes healthy inhibition levels of NF-kB and nitric oxide, reducing inflammatory responses.

  5. Resveratrol (Natural Trans-Resveratrol)

    • Function: Resveratrol is a polyphenol with strong antioxidant and anti-inflammatory properties. It inhibits the activity of pro-inflammatory cytokines and NF-kB.
    • Benefits: Promotes healthy inhibition levels of TNF-α, IL-1 beta, IL-6, NF-kB, contributing to reduced inflammation and oxidative stress.

Research Highlights

 

A study published in the Journal of Pain Research evaluated the efficacy of CytoQuel® in participants with chronic physical discomfort for at least six months. Participants took CytoQuel® for eight weeks, and various markers of inflammation and pain were measured.

  • Physical Discomfort: 65% decrease in pain over eight weeks.
  • Sleep Improvement: 44% improvement in sleep quality over eight weeks.
  • MMP-9: 9.6% reduction in MMP-9 levels, a marker of tissue remodeling and inflammation.
  • Blood Pressure: Ankle brachial index values improved to normal levels.
  • Vascular and Cytokine Markers: Significant reductions in von Willebrand Factor (vWF), fibrinogen, TNF-alpha, and IL-1ra, indicating a reduced inflammatory state.

 

Conclusion

 

CytoQuel® offers a scientifically-backed approach to modulating cytokine levels and supporting a balanced inflammatory response.


Its blend of NAC, black tea extract, CurcuWIN™ turmeric extract, DeltaGold® tocotrienols, and resveratrol works synergistically to reduce oxidative stress and inflammation, providing significant benefits in terms of pain reduction, sleep improvement, and overall vascular health.

 

References

 

  1. Journal of Pain Research (D Hamilton, G Jensen). Pain reduction and improved vascular health associated with daily consumption of an anti-inflammatory dietary supplement blend. J Pain Res. 2019; 12: 1497-1508.
  2. Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005). Curcumin: The story so far. European Journal of Cancer, 41(13), 1955-1968.
  3. Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007). Curcumin: the Indian solid gold. Advances in Experimental Medicine and Biology, 595, 1-75.
  4. Lin, J. K., & Lin-Shiau, S. Y. (2006). Mechanisms of cancer chemoprevention by curcumin. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 25(2), 59-66.
  5. Agarwal, R., & Mukhtar, H. (1996). Tea polyphenols: prevention of cancer and optimizing health. The American Journal of Clinical Nutrition, 66(4), 1085S-1095S.
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